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Insights That Shape the Future of Precision Therapy
Explore the latest updates, scientific perspectives, and strategic insights from across the BIG Platform and our development pipeline.
Featured Insight
Stay up to date with our most recent development milestones, scientific reflections, or leadership commentary. Our featured post highlights the latest movement across the BIG Platform and our lead programs.
Updates, Insights & Perspectives
Stay up to date with the latest news from Onconox — including company milestones, R&D progress, and perspectives from our leadership team. This page is designed to keep our partners, investors, and the wider scientific community informed about our journey and the future of precision-delivered medicine.



AI as a Strategic Partner, Not a Buzzword: What True AI-Driven Drug Development Looks Like
Executive Summary Artificial intelligence has become the most overused — and often misunderstood — term in modern biotech. Dozens of companies now claim to be “AI-driven”, yet only a small fraction have meaningfully integrated AI into the scientific and operational backbone of their organization. For many, AI is a slide deck accessory; for few, it is a strategic partner that shapes decision-making, compresses timelines, and de-risks development. As capital becomes more select
Sep 10


The Coming Shift from Drugs Alone to Multi-Modal Therapeutic Systems
Executive Summary For more than half a century, drug development has centered on a single dominant paradigm: molecules as the primary drivers of therapeutic innovation. But the future is moving toward something fundamentally different — multi-modal therapeutic systems that integrate drugs with localized delivery, AI-guided optimization, biomarkers, imaging, and patient-centric digital tools. These systems do not replace drug innovation; they amplify it , unlocking therapeuti
Jul 9


The Case for Capital-Efficient Biotech: Building More with Less in an Era of Funding Scarcity
Executive Summary The global biotech sector has entered one of its most capital-constrained periods in recent history. Venture dollars have tightened, valuations have recalibrated, and public markets have become increasingly selective. Yet the underlying need for innovation — particularly in oncology, rare disease, and CNS disorders — has never been greater. In this environment, the traditional biotech model of large internal teams, expensive wet-lab infrastructure, and long,
Mar 9


Why Patient Burden Should Be a Core Development Metric in Oncology R&D
Executive Summary For decades, oncology drug development has been measured through two dominant lenses: efficacy and safety . While these remain essential, they no longer tell the full story of whether a therapy truly delivers value in real-world cancer care. An additional dimension — patient burden — is now emerging as a critical determinant of therapeutic success, especially in populations such as non–small cell lung cancer (NSCLC), where most patients are elderly, medica
Oct 16, 2024


Localized Therapy: The Most Overlooked Opportunity in Global Cancer Care
Executive Summary Global cancer care has become increasingly complex, expensive, and systemically burdensome. Despite remarkable innovations in molecular targets and immuno-oncology, many patients worldwide still face challenges linked not to the drug , but to the way drugs are delivered . Toxicity, accessibility, treatment interruptions, and limited applicability to older or medically fragile populations remain persistent barriers. Localized therapy — treatments that act dir
May 15, 2024


How Drug–Device Combinations Will Redefine Precision Medicine Over the Next Decade
Executive Summary For years, precision medicine has been defined almost exclusively through the lens of genomic testing and targeted drugs. But as the field matures, a new reality is becoming clear: precision cannot be achieved through molecules alone . The next decade of innovation will belong to drug–device combinations — technologies that integrate therapeutic agents with delivery systems engineered to ensure the right dose reaches the right place at the right time. From n
Feb 11, 2024


Rethinking Innovation: Why the Future of Oncology Depends on Delivery, Not New Molecules
Executive Summary For more than two decades, oncology innovation has been defined by the pursuit of new targets, new pathways, and new molecular entities. This model has delivered extraordinary breakthroughs — but it has also created diminishing returns, escalating costs, and widening gaps between scientific promise and real-world patient benefit. The next wave of oncology progress is unlikely to come from discovering ever more complex molecules. Instead, it will come from re
Nov 8, 2023
Company News


Onconox Inc. Appoints Geoff Muckle as Chief Executive Officer to Lead Clinical Advancement and Strategic Growth
Summary Onconox Inc. has appointed biotech executive Geoff Muckle as CEO to strengthen the company’s leadership and drive OCN001 toward first-in-human studies in 2026. Geoff brings more than two decades of oncology and biotech experience spanning Roche, Champions Oncology, and Link Medical Solutions, and will lead the company’s evolution from a single-asset entity to a scalable platform-driven biotech. Onconox Inc., a biotechnology company developing precision, low-burden the
Jan 15


Onconox Inc. Appoints Ajay Kambhampati as Non-Executive Director to Strengthen Strategic, Financial, and Governance Oversight
Summary Onconox Inc. has appointed Ajay Kambhampati as a Non-Executive Director. Ajay, one of the company’s original seed investors, brings more than 25 years of experience across healthcare technology, investment, and corporate finance. His strategic, financial, and operational expertise will support Onconox as it advances OCN001 through IND-enabling development and toward future clinical evaluation. Onconox Inc., a biotechnology company advancing a novel therapeutic candida
Nov 1, 2023


Onconox Inc. Appoints Vimta Labs as CRO Partner to Conduct 13-Week Inhalation Toxicology Study for OCN001
Summary Onconox Inc. has selected Vimta Labs Ltd as its contract research organization (CRO) to conduct a pivotal 13-week inhalation toxicology study for its lung-cancer therapeutic candidate OCN001. Vimta’s established capability in inhalation product analysis, GLP-certified facilities, and comprehensive preclinical service suite enables Onconox to advance the program toward IND submission with rigorous, regulatory-aligned safety data. Onconox Inc., a biotechnology company d
Apr 5, 2023
Scientific Insights


Artificial Intelligence in Drug Reformulation and Repurposing: A New Era for Precision Therapeutics
Executive Summary Artificial intelligence (AI) has rapidly transitioned from an experimental tool to a core driver of modern drug development. In the specific domain of reformulation and repurposing — where developers aim to unlock new therapeutic potential from validated pharmacology — AI is proving especially transformative. By integrating data across chemistry, biology, clinical outcomes, and real-world evidence, AI systems can identify promising new indications, optimize
Sep 11


Advances in Nose-to-Brain Delivery for GBM and CNS Disorders
Executive Summary Glioblastoma (GBM) and many central nervous system (CNS) disorders remain among the most challenging conditions to treat, largely due to the inability of many therapeutics to cross the blood–brain barrier (BBB). As a result, researchers and clinicians have increasingly turned their attention toward nose-to-brain delivery — an approach that uses the unique anatomy of the nasal cavity to bypass the BBB and deliver therapeutics directly to the brain. This artic
Mar 11


Combining Novel Localized Therapies with SABR and Chemoradiation: A New Multimodal Paradigm
Executive Summary Stereotactic ablative radiotherapy (SABR) for early stage non–small cell lung cancer (NSCLC) and concurrent chemoradiation (CRT) for unresectable Stage III disease have become essential therapeutic backbones. SABR delivers highly focused, ablative radiation in a few fractions, while CRT provides integrated local and systemic treatment over several weeks. Both approaches are effective but constrained by persistent local progression, distant relapse, and treat
Sep 11, 2024
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